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信号通路相关文献挖掘与分析方法研究(3)

时间:2025-07-04   来源:未知    
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ABSTRACT

,Bioinformaticsisaninterdisciplinarysciencethatdealswithbiologicaldataby

meansofstoring,searchingandperforminganalysiswiththepowerofmodemcomputers.Nowwiththeexplosivegrowthofbiomedicalliteratures,therehavebeenalotofinterestswithinthescientificcommunity

ainhowtocaptureinformationfromthevastcurrentscientificliteraturesinformsuitableforanalysisbycomputer.A

centralprobleminbioinformaticsistodesignliterature-miningtoolstofindthe

totraditionalkey-wordsretrievalnuggetsofinformationfromliteratures.Comparing

method,advantagesofthesetoolsareapparent:fast,automaticandefficientintimeandlaborresources,especiallyinlarge-scalearticleanalysis.

Signalpathwayisthesubstance

aofcells’responsebiologicaltoenvironment.ItplayscrucialregulatoryrolesinvarietyofcdlalaI

andprocesses,includingmetabolism,cell

pathwayhasbeencycle,differentiation,proliferationoneapoptosis,etc.Signalofthemost

areconcernsofmolecularbiologyinrecentyears.Butlotsofvaluableinformationdispersedinvolumesofliterature.It’Squitetimeto

collectthisinformationrelatedwithsignalpathwaytoundersmndthecomprehensivesignalpathway.

Inthisdissertation,someoriginalresearchworkbytheauthor

asCanbeformulatedfclllow:

1.Oeneexpressionisonetheresultofsignalpathway,andtranscriptionfactors

onplaypivotrolesinthisprogress.AliteratureminingmethodbasedBayesianis

firstproposedtoretrievearticlesdescribingbindingsitesoftranscriptionfactor.By

statisticallyidentifyingwordsthatdiscriminate

eachnewabstractcanrelevantabstractsfromotherabstracts,scorethenbeassignedaloglikelihoodfordiscussingbindingsiteoftranscriptionfactors,Wejustattestthatthismethodis

onsimilarwithclassicalinformationretrievalmethodwhichisbasedTF/IDFtheory.Theefficiencyofthis

methodisimprovedgreatlybycombiningwithrelatedarticlesmethodof

TherecallrateandprecisionrateofOurmethod

traditionalkey-wordarePubMed.91%and45%,whichoutperforms

PubMedmethod(recallarate<=83%andprecisionrate<=26%respective).Althoughourmethodhaslittlelowerrecallratethansolerelatedar

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